{"id":20589,"date":"2021-05-07T13:49:15","date_gmt":"2021-05-07T13:49:15","guid":{"rendered":"https:\/\/evaggelatos.com\/?p=20589"},"modified":"2021-05-07T14:25:33","modified_gmt":"2021-05-07T14:25:33","slug":"%ce%b7-%ce%b9%ce%bd%ce%b2%ce%b5%cf%81%ce%bc%ce%b5%ce%ba%cf%84%ce%af%ce%bd%ce%b7-scaball-%ce%ba%ce%b1%ce%b9-%cf%84%ce%bf-plaquenil-%ce%b8%ce%b5%ce%b9%cf%8a%ce%ba%ce%ae-%cf%85%ce%b4%cf%81%ce%bf%ce%be","status":"publish","type":"post","link":"https:\/\/evaggelatos.com\/?p=20589","title":{"rendered":"\u0397 \u03b9\u03bd\u03b2\u03b5\u03c1\u03bc\u03b5\u03ba\u03c4\u03af\u03bd\u03b7 Scaball) \u03ba\u03b1\u03b9 \u03c4\u03bf Plaquenil (\u03b8\u03b5\u03b9\u03ca\u03ba\u03ae \u03c5\u03b4\u03c1\u03bf\u03be\u03c5\u03c7\u03bb\u03c9\u03c1\u03bf\u03ba\u03af\u03bd\u03b7) \u03c6\u03b1\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bd\u03b1 \u03b1\u03ba\u03b9\u03bd\u03b7\u03c4\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03bd \u03ba\u03b1\u03b9 \u03bd\u03b1 \u03b5\u03bc\u03c0\u03bf\u03b4\u03af\u03b6\u03bf\u03c5\u03bd \u03c4\u03bf\u03bd \u03c0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03b1\u03c3\u03b9\u03b1\u03c3\u03bc\u03cc \u03c4\u03bf\u03c5 Covid-19"},"content":{"rendered":"<div class=\"td-pb-row\">\n<div class=\"td-pb-span12\">\n<div class=\"td-post-header\">\n<header class=\"td-post-title\">\n<h1 class=\"entry-title\">AIIMS Bhubaneswar finds deworming drug ivermectin, used in Delhi to treat Covid, is effective<\/h1>\n<h2 class=\"td-post-sub-title\">The national treatment guidelines for Covid do not include the drug due to lack of enough evidence, say officials.<\/h2>\n<div class=\"td-module-meta-info\"><a class=\"author url fn\" title=\"Posts by Abantika Ghosh\" href=\"https:\/\/theprint.in\/author\/abantika-ghosh\/\" rel=\"author\">Abantika Ghosh<\/a> <span class=\"update_date\">7 November, 2020<br \/>\n<\/span><\/div>\n<\/header>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"td-pb-row\">\n<div class=\"td-pb-span8 td-main-content\" role=\"main\">\n<div class=\"td-ss-main-content\">\n<div class=\"td-post-sharing-top\">\n<div id=\"td_social_sharing_article_top\" class=\"td-post-sharing td-ps-bg td-ps-notext td-ps-rounded td-post-sharing-style3 \">\n<div class=\"td-post-sharing-visible\">\n<div class=\"td-social-but-icon\"><\/div>\n<\/div>\n<div class=\"td-social-sharing-hidden\">\n<div class=\"td-social-but-icon\"><\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"td-post-content tagdiv-type\">\n<div class=\"td-post-featured-image\">\n<figure><img loading=\"lazy\" decoding=\"async\" class=\"entry-thumb\" title=\"A file photo of the All India Institute of Medical Sciences (AIIMS), New Delhi. | Manisha Mondal | ThePrint\" src=\"https:\/\/static.theprint.in\/wp-content\/uploads\/2020\/07\/aiims3-696x392.jpg\" sizes=\"auto, (max-width: 696px) 100vw, 696px\" srcset=\"https:\/\/static.theprint.in\/wp-content\/uploads\/2020\/07\/aiims3-696x392.jpg 696w, https:\/\/static.theprint.in\/wp-content\/uploads\/2020\/07\/aiims3-300x169.jpg 300w, https:\/\/static.theprint.in\/wp-content\/uploads\/2020\/07\/aiims3-1024x576.jpg 1024w, https:\/\/static.theprint.in\/wp-content\/uploads\/2020\/07\/aiims3-768x432.jpg 768w, https:\/\/static.theprint.in\/wp-content\/uploads\/2020\/07\/aiims3-1068x601.jpg 1068w, https:\/\/static.theprint.in\/wp-content\/uploads\/2020\/07\/aiims3-747x420.jpg 747w, https:\/\/static.theprint.in\/wp-content\/uploads\/2020\/07\/aiims3.jpg 1200w\" alt=\"A file photo of the All India Institute of Medical Sciences (AIIMS), New Delhi. | Manisha Mondal | ThePrint\" width=\"696\" height=\"392\" \/><figcaption class=\"wp-caption-text\">A file photo of the All India Institute of Medical Sciences (AIIMS), New Delhi. | Manisha Mondal | ThePrint<\/figcaption><\/figure>\n<\/div>\n<div class=\"fontsize_Btn\">Text Size:<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<p><strong>New Delhi:<\/strong> As India continues to use <strong>hydroxychloroquine both for treatment and prophylaxis of Covid-19<\/strong> despite several studies questioning the efficacy of the drug in either role, an AIIMS Bhubaneswar study has flagged a possible prophylactic function of deworming drug ivermectin for the novel coronavirus.<\/p>\n<p>The national Covid management guidelines do not advise the drug\u2019s use. However, it has been in use for Covid treatment at AIIMS in the national capital right from the start of the pandemic and with satisfactory results, say doctors at India\u2019s premier medical institute.<\/p>\n<p>Ivermectin is an anti-parasitic drug. It acts by impeding the role of cell proteins that are hijacked by an invading pathogen and thus is conceived to have a role beyond the known, including against the SARS-CoV2 virus.<\/p>\n<p>The <a href=\"https:\/\/www.medrxiv.org\/content\/10.1101\/2020.10.29.20222661v1\" target=\"_blank\" rel=\"noopener noreferrer\">pre-print study<\/a> from Bhubaneswar earlier this week concluded:<strong> \u201cTwo-dose ivermectin prophylaxis at a dose of 300 \u03bcg\/kg with a gap of 72 hours was associated 73% reduction of COVID-19 infection among healthcare workers for the following one-month<\/strong>. Further research is required before its large scale use.\u201d<\/p>\n<p>The drug was tested in 186 case-control pairs. The paper also made the point tha<strong>t the \u201cuse of hydroxychloroquine (HCQ) as chemoprophylaxis was used in India under the recommendation of a few experts with little evidence and lack of scientific data\u201d.<\/strong><\/p>\n<p>Last month, the national task force on Covid discussed ivermectin in a meeting but decided against including it in the national clinical management protocol citing lack of enough evidence, according to health ministry officials who didn\u2019t wish to be named.<\/p>\n<hr \/>\n<h3><strong>AIIMS has been using ivermectin for Covid since 3 <\/strong><strong>April <\/strong><\/h3>\n<p>Ivermectin is normally used as a deworming medication. However, the drug is being used \u201cfrom day one\u201d at AIIMS, said Dr Anjan Trikha professor of anaesthesiology, pain and critical care, at the institute.<\/p>\n<p>\u201cWe have been using it since 3 April and we are still using it \u2014 12 mg for three days. Obviously we have had a good experience. That is why we have continued. We are using it because it is relatively safe, with chances of potential complications being less, and it is cheap,\u201d said Trikha.<\/p>\n<p>\u201cThere was also a study on prophylaxis but we are not using it institutionally for that purpose. Some people may choose to take it. We are using it in confirmed Covid cases. It is not approved for Covid but there are so many things that aren\u2019t including monoclonal antibodies which President Donald Trump took,\u201d he added.<\/p>\n<p>Some studies have found that ivermectin is associated with reduced mortality in Covid patients, in some cases by <strong>up to 40 per cent.<\/strong><\/p>\n<p><strong>A US study published in the journal <em>Chest<\/em> <a href=\"https:\/\/journal.chestnet.org\/article\/S0012-3692(20)34898-4\/fulltext\" target=\"_blank\" rel=\"noopener noreferrer\">found<\/a>: \u201cIn this multihospital retrospective cohort study, we observed a significant association of ivermectin with improved survival for patients admitted with COVID-19. This association also was seen in the subset of patients with severe pulmonary disease.\u201d<\/strong><\/p>\n<p>It added, \u201cThese findings were confirmed after multivariate adjustment for comorbidities and differences between groups, and also in a propensity score-matched cohort. Similar to other studies, we noted that older age, cardiac disease, current or former smoking, more severe pulmonary involvement at presentation, higher WBC counts, and lower lymphocyte counts emerged as risk markers for in-hospital mortality.\u201d<\/p>\n<hr \/>\n<p><em><strong>Also read:<\/strong>\u00a0<a href=\"https:\/\/theprint.in\/health\/good-news-from-indias-covid-battle-fatality-rate-is-down-50-since-may\/537963\/\" target=\"_blank\" rel=\"noopener noreferrer\">Good news from India\u2019s Covid battle \u2014 fatality rate is down 50% since May<\/a><\/em><\/p>\n<hr \/>\n<h3><strong>How it works<\/strong><\/h3>\n<p><span style=\"font-size: 14pt;\"><strong>Studies <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0166354220302011\" target=\"_blank\" rel=\"noopener noreferrer\">have shown<\/a> that ivermectin can stop viral replication in cell cultures (outside the body) within 24-48 hours using a mechanism that prevents viral proteins from invading the nucleus of the host cell and thus taking over its replication machinery.<\/strong><\/span><\/p>\n<p>The problem, however, is that the dosage that is required to achieve this effect is far more than what is approved for use in humans.<\/p>\n<p>In its <a href=\"https:\/\/www.covid19treatmentguidelines.nih.gov\/antiviral-therapy\/ivermectin\/\" target=\"_blank\" rel=\"noopener noreferrer\">Covid treatment guidelines update<\/a> in August, <strong>the National Institutes of Health in the US wrote that ivermectin has been shown to \u201cinhibit the replication\u201d of SARS-CoV-2 in cell cultures.<\/strong> \u201cHowever, pharmacokinetic and pharmacodynamic studies suggest that achieving the plasma concentrations necessary for the antiviral efficacy detected in vitro would require administration of doses up to 100-fold higher than those approved for use in humans,\u201d it said.<\/p>\n<p>\u201cEven though ivermectin appears to accumulate in the lung tissue, predicted systemic plasma and lung tissue concentrations are much lower than 2 \u00b5M, the half-maximal inhibitory concentration against SARS-CoV-2 in vitro,\u201d it said.<\/p>\n<p>\u201cIvermectin is not approved for the treatment of any viral infection, including SARS-CoV-2 infection. The FDA issued a warning in April 2020 that ivermectin intended for use in animals should not be used to treat COVID-19 in humans,\u201d it added.<\/p>\n<p>SOURCE:https:\/\/theprint.in\/health\/aiims-bhubaneswar-study-finds-ivermectin-prevents-covid-in-delhi-it-is-used-for-treatment-too\/539082\/<\/p>\n","protected":false},"excerpt":{"rendered":"<p>AIIMS Bhubaneswar finds deworming drug ivermectin, used in Delhi to treat Covid, is effective The national treatment guidelines for Covid do not include the drug due to lack of enough evidence, say officials. Abantika Ghosh 7 November, 2020 A file photo of the All India Institute of Medical Sciences (AIIMS), New Delhi. | Manisha Mondal &hellip; <\/p>\n<p><a class=\"more-link btn\" href=\"https:\/\/evaggelatos.com\/?p=20589\">\u03a3\u03c5\u03bd\u03ad\u03c7\u03b5\u03b9\u03b1 \u03b1\u03bd\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7\u03c2<\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[42],"tags":[244],"class_list":["post-20589","post","type-post","status-publish","format-standard","hentry","category-42","tag-244","item-wrap"],"_links":{"self":[{"href":"https:\/\/evaggelatos.com\/index.php?rest_route=\/wp\/v2\/posts\/20589","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/evaggelatos.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/evaggelatos.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/evaggelatos.com\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/evaggelatos.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=20589"}],"version-history":[{"count":2,"href":"https:\/\/evaggelatos.com\/index.php?rest_route=\/wp\/v2\/posts\/20589\/revisions"}],"predecessor-version":[{"id":20594,"href":"https:\/\/evaggelatos.com\/index.php?rest_route=\/wp\/v2\/posts\/20589\/revisions\/20594"}],"wp:attachment":[{"href":"https:\/\/evaggelatos.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=20589"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/evaggelatos.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=20589"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/evaggelatos.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=20589"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}