{"id":20623,"date":"2021-05-10T16:19:09","date_gmt":"2021-05-10T16:19:09","guid":{"rendered":"https:\/\/evaggelatos.com\/?p=20623"},"modified":"2021-05-10T16:47:02","modified_gmt":"2021-05-10T16:47:02","slug":"%ce%b4%cf%81-%ce%b4-%ce%b1%ce%bd%cf%84%cf%89%ce%bd%ce%af%ce%bf%cf%85-%ce%b7-%cf%80%cf%81%ce%bf%cf%84%ce%b5%ce%b9%ce%bd%cf%8c%ce%bc%ce%b5%ce%bd%ce%b7-%ce%b8%ce%b5%cf%81%ce%b1%cf%80%ce%b5%ce%af%ce%b1","status":"publish","type":"post","link":"https:\/\/evaggelatos.com\/?p=20623","title":{"rendered":"\u0394\u03c1. \u0394\u03b7\u03bc. \u0391\u03bd\u03c4\u03c9\u03bd\u03af\u03bf\u03c5: \u0397 \u03c0\u03c1\u03bf\u03c4\u03b5\u03b9\u03bd\u03cc\u03bc\u03b5\u03bd\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03bc\u03b5 Methotrexate \u03ba\u03b9 \u0391\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03b5\u03af\u03c2 \u03c4\u03b7\u03c2 \u0391\u03b3\u03b3\u03b5\u03b9\u03bf\u03c4\u03b5\u03bd\u03c3\u03af\u03bd\u03b7\u03c2-2."},"content":{"rendered":"<p>\u039f\u00a0<strong><a href=\"https:\/\/tgnews.gr\/?s=%CE%91%CE%BD%CF%84%CF%89%CE%BD%CE%AF%CE%BF%CF%85\" target=\"_blank\" rel=\"noopener noreferrer\">\u0394\u03c1. \u0394\u03b7\u03bc\u03ae\u03c4\u03c1\u03b9\u03bf\u03c2 \u0391\u03bd\u03c4\u03c9\u03bd\u03af\u03bf\u03c5 PhD, FRCS<\/a><\/strong>\u00a0\u03c0\u03c1\u03bf\u03c4\u03b5\u03af\u03bd\u03b5\u03b9 \u03c4\u03b7\u03bd \u03b1\u03bd\u03c4\u03b9\u03bc\u03b5\u03c4\u03ce\u03c0\u03b9\u03c3\u03b7 \u03c4\u03bf\u03c5 Covid \u03bc\u03b5 \u03c6\u03b8\u03b7\u03bd\u03ac \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03b1 \u03c4\u03b1 \u03bf\u03c0\u03bf\u03af\u03b1 \u03c7\u03bf\u03c1\u03b7\u03b3\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03b3\u03b9\u03b1 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03c0\u03b1\u03b8\u03ae\u03c3\u03b5\u03b9\u03c2 \u03ba\u03b1\u03b9 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b4\u03b9\u03b1\u03b8\u03ad\u03c3\u03b9\u03bc\u03b1 \u03c3\u03c4\u03bf \u03c6\u03b1\u03c1\u03bc\u03b1\u03ba\u03b5\u03af\u03b1. \u03a3\u03c4\u03bf \u03c0\u03b1\u03c1\u03cc\u03bd \u03ac\u03c1\u03b8\u03c1\u03bf \u03b5\u03be\u03b7\u03b3\u03b5\u03af \u03c4\u03b7\u03bd \u03b4\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03af\u03b1 \u03c0\u03bf\u03c5 \u03b8\u03b1 \u03c0\u03c1\u03cc\u03c4\u03b5\u03b9\u03bd\u03b5 \u03c3\u03c4\u03bf\u03c5\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03c4\u03bf\u03c5, \u03c0\u03c1\u03bf\u03c4\u03c1\u03ad\u03c0\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c4\u03b7\u03bd \u03ba\u03bf\u03b9\u03bd\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03ae \u03c4\u03bf\u03c5\u03c2 \u03ce\u03c3\u03c4\u03b5 \u03bd\u03b1 \u03b3\u03bd\u03c9\u03c1\u03af\u03b6\u03b5\u03b9 \u03bf \u03ba\u03cc\u03c3\u03bc\u03bf\u03c2.<img loading=\"lazy\" decoding=\"async\" class=\"attachment-slide size-slide wp-post-image\" title=\"\" src=\"https:\/\/www.triklopodia.gr\/wp-content\/uploads\/2021\/05\/d6e65d2942365b659abc12b7f8187aef154d7043-1280x720-1-1068x539-1-940x450.png\" alt=\"\" width=\"940\" height=\"450\" \/><a href=\"https:\/\/evaggelatos.com\/wp-content\/uploads\/2021\/05\/Colloidal_nanoparticle_of_lead_sulfide_selenide_with_complete_passivation.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-large wp-image-20625\" src=\"https:\/\/evaggelatos.com\/wp-content\/uploads\/2021\/05\/Colloidal_nanoparticle_of_lead_sulfide_selenide_with_complete_passivation.png\" alt=\"\" width=\"220\" height=\"201\" \/><\/a><\/p>\n<p>\u03a0\u03c1\u03bf\u03c4\u03b5\u03b9\u03bd\u03cc\u03bc\u03b5\u03bd\u03b7 \u03b8\u03b5\u03c9\u03c1\u03b7\u03c4\u03b9\u03ba\u03ac \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03bc\u03b5 \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03b1 \u03b3\u03b9\u03b1 \u03c4\u03bf\u03bd \u03ba\u03bf\u03c1\u03bf\u03bd\u03bf\u03b9\u03cc: Methotrexate (\u03b3\u03b9\u03b1 \u03b1\u03c5\u03c4\u03bf\u03ac\u03bd\u03bf\u03c3\u03b1 \u03bd\u03bf\u03c3\u03ae\u03bc\u03b1\u03c4\u03b1) \u03ba\u03b9 \u0391\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03b5\u03af\u03c2 \u03c4\u03b7\u03c2 \u0391\u03b3\u03b3\u03b5\u03b9\u03bf\u03c4\u03b5\u03bd\u03c3\u03af\u03bd\u03b7\u03c2-2 (\u03b1\u03bd\u03c4\u03b9-\u03c5\u03c0\u03b5\u03c1\u03c4\u03b1\u03c3\u03b9\u03ba\u03cc)<\/p>\n<p><strong>\u0394\u03c1. \u0394\u03b7\u03bc\u03ae\u03c4\u03c1\u03b9\u03bf\u03c2 \u0391\u03bd\u03c4\u03c9\u03bd\u03af\u03bf\u03c5 PhD, FRCS<\/strong><\/p>\n<p><strong>\u0394\u039f\u03a3\u039f\u039b\u039f\u0393\u0399\u0391 Methotrexate:<\/strong> 2 \u03c7\u03ac\u03c0\u03b9\u03b1 \u03bc\u03b1\u03b6\u03af (2X2.5mg) \u03ba\u03ac\u03b8\u03b5 12 \u03ce\u03c1\u03b5\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03c1\u03b5\u03b9\u03c2 \u03c6\u03bf\u03c1\u03ad\u03c2 (\u03c3\u03cd\u03bd\u03bf\u03bb\u03bf 6 \u03c7\u03ac\u03c0\u03b9\u03b1). \u0395\u03c0\u03b1\u03bd\u03b1\u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03b5\u03c4\u03b5 \u03bc\u03b5\u03c4\u03ac 1 \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03b1, \u03bc\u03ad\u03c7\u03c1\u03b9 \u03bd\u03b1 \u03b3\u03af\u03bd\u03b5\u03c4\u03b5 \u03ba\u03b1\u03bb\u03ac (\u03bd\u03bf\u03bc\u03af\u03b6\u03c9 \u03bc\u03b5 2 \u03ba\u03cd\u03ba\u03bb\u03bf\u03c5\u03c2 \u03b8\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03cc\u03bb\u03b1 \u03ba\u03b1\u03bb\u03ac (\u03ba\u03ac\u03b8\u03b5 \u03c7\u03ac\u03c0\u03b9 \u03c0\u03b5\u03c1\u03b9\u03ad\u03c7\u03b5\u03b9 2.5mg methotrexate) (\u03b2\u03bb.\u03ba\u03b1\u03b9 \u03c0\u03b1\u03c1\u03b1\u03ba\u03ac\u03c4\u03c9, \u03c6\u03c9\u03c4\u03bf\u03b3\u03c1\u03b1\u03c6\u03af\u03b1 \u03c4\u03bf\u03c5 \u03c6\u03c5\u03bb\u03bb\u03b1\u03b4\u03af\u03bf\u03c5 \u03c4\u03b7\u03c2 methotrexate \u03c4\u03b7\u03c2 \u03b5\u03c4\u03b1\u03b9\u03c1\u03b5\u03af\u03b1\u03c2 Pfizer).<\/p>\n<p>\u0395\u03c0\u03b5\u03b9\u03b4\u03ae \u03b7 \u03c0\u03c1\u03cc\u03bb\u03b7\u03c8\u03b7 (\u03ba\u03b9 \u03cc\u03c7\u03b9 \u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1) \u03bc\u03b5 \u03c4\u03bf \u03b5\u03bc\u03b2\u03cc\u03bb\u03b9\u03bf \u03ba\u03b1\u03c4\u03ac \u03c4\u03bf\u03c5 \u03ba\u03bf\u03c1\u03bf\u03bd\u03bf\u03ca\u03bf\u03cd, \u03b1\u03c0\u03b5\u03b4\u03b5\u03af\u03c7\u03b8\u03b7 \u03bc\u03b9\u03b1 \u0391\u03a0\u0391\u03a4\u0397 (\u03cc\u03c0\u03c9\u03c2 \u03c4\u03b1 \u03c6\u03ce\u03bd\u03b1\u03b6\u03b1 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03c0\u03c1\u03ce\u03c4\u03b7 \u03c3\u03c4\u03b9\u03b3\u03bc\u03ae) \u03ba\u03b9 \u03b5\u03c0\u03b5\u03b9\u03b4\u03ae, \u03bf \u03b5\u03bc\u03b2\u03bf\u03bb\u03b9\u03b1\u03c3\u03bc\u03cc\u03c2 \u03c3\u03b5 \u03ba\u03ac\u03b8\u03b5 \u03c0\u03b5\u03c1\u03af\u03c0\u03c4\u03c9\u03c3\u03b7 \u03b4\u03b5\u03bd \u00ab\u03c3\u03ba\u03bf\u03c4\u03ce\u03bd\u03b5\u03b9\u00bb \u03b1\u03c0\u03b5\u03c5\u03b8\u03b5\u03af\u03b1\u03c2 \u03c4\u03bf\u03bd \u03b9\u03cc (\u03b3\u03b9` \u03b1\u03c5\u03c4\u03cc \u03ba\u03b1\u03b9 \u03b4\u03b5\u03bd \u03b8\u03b5\u03c9\u03c1\u03b5\u03af\u03c4\u03b1\u03b9 \u03c9\u03c2 \u03c0\u03c1\u03b1\u03b3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1, \u03cc\u03c0\u03c9\u03c2 \u03b1\u03bd\u03c4\u03af\u03b8\u03b5\u03c4\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c4\u03b1 \u03b1\u03bd\u03c4\u03b9\u03b2\u03b9\u03bf\u03c4\u03b9\u03ba\u03ac \u03c0\u03bf\u03c5 \u03c3\u03ba\u03bf\u03c4\u03ce\u03bd\u03bf\u03c5\u03bd \u03b1\u03c0\u03b5\u03c5\u03b8\u03b5\u03af\u03b1\u03c2 \u03c4\u03b1 \u03ba\u03bf\u03b9\u03bd\u03ac \u03bc\u03b9\u03ba\u03c1\u03cc\u03b2\u03b9\u03b1), \u03b3\u03b9` \u03b1\u03c5\u03c4\u03cc \u03a4\u039f\u039b\u039c\u03a9 \u03bd\u03b1 \u03c0\u03c1\u03bf\u03c4\u03b5\u03af\u03bd\u03c9 \u03bc\u03b9\u03b1 \u03c0\u03c1\u03b1\u03b3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03c4\u03bf\u03c5 \u03ba\u03bf\u03c1\u03bf\u03bd\u03bf\u03ca\u03bf\u03cd, \u03bc\u03b5 \u03b4\u03cd\u03bf \u03b3\u03bd\u03c9\u03c3\u03c4\u03ac \u03ba\u03b1\u03b9 \u03c6\u03b8\u03b7\u03bd\u03ac \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03b1 (\u03c0\u03bf\u03c5 \u03b4\u03af\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03bf \u03c3\u03c4\u03cc\u03bc\u03b1), \u03c4\u03bf \u03ad\u03bd\u03b1 \u03b5\u03ba \u03c4\u03c9\u03bd \u03bf\u03c0\u03bf\u03af\u03c9\u03bd \u03b4\u03c1\u03b1 \u03ad\u03bc\u03bc\u03b5\u03c3\u03b1 \u03ba\u03b1\u03c4\u03ac \u03c4\u03bf\u03c5 \u03ba\u03bf\u03c1\u03bf\u03bd\u03bf\u03b9\u03bf\u03cd (\u03b4\u03b5\u03bd \u03c4\u03bf\u03bd \u03c3\u03ba\u03bf\u03c4\u03ce\u03bd\u03b5\u03b9 \u03b1\u03c0` \u03b5\u03c5\u03b8\u03b5\u03af\u03b1\u03c2)(\u03bf\u03b9 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03b5\u03af\u03c2 \u03c4\u03b7\u03c2 \u0391\u03b3\u03b3\u03b5\u03b9\u03bf\u03c4\u03b5\u03bd\u03c3\u03af\u03bd\u03b7\u03c2-2) \u03ba\u03b1\u03b9 \u03c4\u03bf \u03ac\u03bb\u03bb\u03bf (\u03b7 \u039cethotrexate) \u03c4\u03bf\u03bd \u03c3\u03ba\u03bf\u03c4\u03ce\u03bd\u03b5\u03b9 \u03ac\u03bc\u03b5\u03c3\u03b1 \u03ba\u03b9 \u03b1\u03c0\u03b5\u03c5\u03b8\u03b5\u03af\u03b1\u03c2.<\/p>\n<p><strong>\u03a0\u03a1\u039f\u03a3\u039f\u03a7\u0397 \u039f\u039c\u03a9\u03a3:<\/strong> \u0397 \u03c0\u03b1\u03c1\u03bf\u03cd\u03c3\u03b1 \u201c\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u201d \u03bc\u03b5 \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03b1 \u03b3\u03b9\u03b1 \u03c4\u03bf\u03bd \u03ba\u03bf\u03c1\u03bf\u03bd\u03bf\u03b9\u03cc: \u0391\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03b5\u03af\u03c2 \u03c4\u03b7\u03c2 \u0391\u03b3\u03b3\u03b5\u03b9\u03bf\u03c4\u03b5\u03bd\u03c3\u03af\u03bd\u03b7\u03c2-2 (\u03b1\u03bd\u03c4\u03b9-\u03c5\u03c0\u03b5\u03c1\u03c4\u03b1\u03c3\u03b9\u03ba\u03cc) \u03ba\u03b1\u03b9 Methotrexate (\u03b3\u03b9\u03b1 \u03b1\u03c5\u03c4\u03bf\u03ac\u03bd\u03bf\u03c3\u03b1 \u03bd\u03bf\u03c3\u03ae\u03bc\u03b1\u03c4\u03b1), \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03b9\u03b1 \u03b4\u03b9\u03ba\u03ae \u03bc\u03bf\u03c5 \u0399\u0394\u0395\u0391, \u03b7 \u03bf\u03c0\u03bf\u03af\u03b1 \u03b2\u03ad\u03b2\u03b5\u03b9\u03b1 \u03c3\u03c4\u03b7\u03c1\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc\u03bb\u03c5\u03c4\u03b1 \u03c3\u03c4\u03bf\u03c5\u03c2 \u03ba\u03b1\u03bd\u03cc\u03bd\u03b5\u03c2 \u03c4\u03b7\u03c2 \u0399\u03b1\u03c4\u03c1\u03b9\u03ba\u03ae\u03c2, \u03b1\u03bb\u03bb\u03ac \u03b3\u03b9\u03b1 \u03bd\u03b1 \u03c0\u03ac\u03c1\u03b5\u03b9 \u03ac\u03b4\u03b5\u03b9\u03b1 \u03c7\u03c1\u03ae\u03c3\u03b7\u03c2 \u03c4\u03b7\u03c2, \u03b1\u03c0\u03b1\u03b9\u03c4\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03bd\u03b1 \u03b1\u03ba\u03bf\u03bb\u03bf\u03c5\u03b8\u03ae\u03c3\u03bf\u03c5\u03bd \u03bf\u03b9 \u03b4\u03b9\u03b1\u03b4\u03b9\u03ba\u03b1\u03c3\u03af\u03b5\u03c2 \u03c0\u03bf\u03c5 \u03c0\u03c1\u03bf\u03b2\u03bb\u03ad\u03c0\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03bf\u03bd \u03bd\u03cc\u03bc\u03bf \u03ba\u03b1\u03b9 \u03c4\u03bf\u03c5\u03c2 \u03ba\u03b1\u03bd\u03cc\u03bd\u03b5\u03c2 \u03c4\u03b7\u03c2 \u03b9\u03b1\u03c4\u03c1\u03b9\u03ba\u03ae\u03c2 \u03b7\u03b8\u03b9\u03ba\u03ae\u03c2, \u03ce\u03c3\u03c4\u03b5 \u03bd\u03b1 \u03c0\u03b9\u03c3\u03c4\u03bf\u03bf\u03c0\u03bf\u03b9\u03b7\u03b8\u03b5\u03af \u03b7 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03b7\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2 \u03b1\u03c5\u03c4\u03ae\u03c2, \u03b7 \u03b4\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03af\u03b1 \u03c4\u03b7\u03c2 \u03ba\u03bb\u03c0 \u03ba\u03bb\u03c0. \u0393\u03b9` \u03b1\u03c5\u03c4\u03cc \u03c4\u03b7\u03bd \u03ad\u03c7\u03c9 \u03c0\u03c1\u03bf\u03c4\u03b5\u03af\u03bd\u03b5\u03b9 \u03b1\u03c0\u03cc \u03c0\u03ad\u03c1\u03b9\u03c3\u03c5 \u03c3\u03c4\u03bf\u03bd \u0395\u039f\u0394\u03a5 \u03ba\u03b1\u03b9 \u03c4\u03bf\u03c5 \u03a5\u03c0\u03bf\u03c5\u03c1\u03b3\u03b5\u03af\u03bf, \u03c4\u03b1 \u03bf\u03c0\u03bf\u03af\u03b1, \u03c9\u03c2 \u03c3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03bc\u03b5 \u03ad\u03c7\u03bf\u03c5\u03bd \u03b1\u03b3\u03bd\u03bf\u03ae\u03c3\u03b5\u03b9.<\/p>\n<p>\u03a0\u0391\u039d\u03a4\u03a9\u03a3, \u0391\u03a1\u039a\u0395\u03a4\u039f\u0399 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u03c3\u03c5\u03bc\u03c0\u03c4\u03ce\u03bc\u03b1\u03c4\u03b1 \u03ba\u03bf\u03c1\u03bf\u03bd\u03bf\u03ca\u03bf\u03cd, \u03c0\u03bf\u03c5 \u03c0\u03ae\u03c1\u03b1\u03bd \u03b1\u03c0\u03cc \u03bc\u03cc\u03bd\u03bf\u03b9 \u03c4\u03bf\u03c5\u03c2 \u03c4\u03b7\u03bd \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03b1\u03c5\u03c4\u03ae, \u03ae \u03c4\u03bf \u03ad\u03bd\u03b1 \u03ae \u03c4\u03bf \u03ac\u03bb\u03bb\u03bf \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03bf (\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03c4\u03b7\u03bd Methotrexate)-\u03b5\u03bd \u03b1\u03b3\u03bd\u03bf\u03af\u03b1 \u03bc\u03bf\u03c5-\u03b5\u03ba \u03c4\u03c9\u03bd \u03c5\u03c3\u03c4\u03ad\u03c1\u03c9\u03bd \u03bc\u03bf\u03c5 \u03b5\u03af\u03c0\u03b1\u03bd \u03cc\u03c4\u03b9 \u201c\u03ad\u03b3\u03b9\u03bd\u03b1\u03bd \u03b1\u03bc\u03ad\u03c3\u03c9\u03c2 \u03ba\u03b1\u03bb\u03ac\u201d\u2026!!<\/p>\n<p><strong>Methotrexate:<\/strong> \u039b\u03b1\u03bc\u03b2\u03ac\u03bd\u03b5\u03c4\u03b1\u03b9 \u03cc\u03c4\u03b1\u03bd \u03ad\u03c7\u03b5\u03c4\u03b5 \u03ba\u03bf\u03c1\u03bf\u03bd\u03bf\u03b9\u03cc, \u03b5\u03af\u03c4\u03b5 \u03bc\u03b5 \u03c3\u03c5\u03bc\u03c0\u03c4\u03ce\u03bc\u03b1\u03c4\u03b1 \u03b5\u03af\u03c4\u03b5 \u03cc\u03c7\u03b9, \u03b4\u03b7\u03bb\u03b1\u03b4\u03ae \u03cc\u03c4\u03b1\u03bd \u03ad\u03c7\u03b5\u03c4\u03b5 \u03b8\u03b5\u03c4\u03b9\u03ba\u03cc \u03c4\u03b5\u03c3\u03c4 (\u03b4\u03b5\u03bd \u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03b5\u03c4\u03b1\u03b9 \u03c0\u03c1\u03bf\u03bb\u03b7\u03c0\u03c4\u03b9\u03ba\u03ac). \u03a0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03bc\u03b7\u03bd \u03ad\u03c7\u03b5\u03c4\u03b5 \u03c0\u03c1\u03cc\u03b2\u03bb\u03b7\u03bc\u03b1 \u03bc\u03b5 \u03c4\u03bf \u03c3\u03c5\u03ba\u03ce\u03c4\u03b9 \u03c3\u03b1\u03c2, \u03b3\u03b9` \u03b1\u03c5\u03c4\u03cc \u03c3\u03b5 \u03c4\u03ad\u03c4\u03bf\u03b9\u03b1 \u03c5\u03c0\u03bf\u03c8\u03af\u03b1 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03ba\u03ac\u03bd\u03b5\u03c4\u03b5 \u03c0\u03c1\u03ce\u03c4\u03b1 \u03b5\u03be\u03b5\u03c4\u03ac\u03c3\u03b5\u03b9\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03bf \u03c3\u03c5\u03ba\u03ce\u03c4\u03b9 \u03c3\u03b1\u03c2 \u03ba\u03b9 \u03b1\u03bd \u03ad\u03c7\u03b5\u03c4\u03b5 \u03ba\u03ac\u03c4\u03b9, \u03bd\u03b1 \u03bc\u03b7\u03bd \u03c0\u03ac\u03c1\u03b5\u03c4\u03b5 \u03c4\u03bf \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03bf.<\/p>\n<p>\u0395\u03af\u03bd\u03b1\u03b9 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ad\u03b1\u03c2 \u03c4\u03bf\u03c5 \u03c6\u03c5\u03bb\u03bb\u03b9\u03ba\u03bf\u03cd \u03bf\u03be\u03ad\u03c9\u03c2. \u03a4\u03bf mRNA \u03c4\u03bf\u03c5 \u03b9\u03bf\u03cd \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03af\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c7\u03b7\u03bc\u03b9\u03ba\u03ad\u03c2 \u03bf\u03c5\u03c3\u03af\u03b5\u03c2 \u03c0\u03bf\u03c5 \u03bb\u03ad\u03b3\u03bf\u03bd\u03c4\u03b1\u03b9 \u00ab\u03b2\u03ac\u03c3\u03b5\u03b9\u03c2\u00bb, \u03bc\u03b5\u03c4\u03b1\u03be\u03cd \u03c4\u03c9\u03bd \u03bf\u03c0\u03bf\u03af\u03c9\u03bd \u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03ba\u03b1\u03b9 \u03bf\u03b9 \u03a0\u03bf\u03c5\u03c1\u03af\u03bd\u03b7 \u03ba\u03b1\u03b9 \u03a0\u03c5\u03c1\u03b9\u03bc\u03b9\u03b4\u03af\u03bd\u03b7, \u03c4\u03c9\u03bd \u03bf\u03c0\u03bf\u03af\u03c9\u03bd \u03cc\u03bc\u03c9\u03c2 \u03b1\u03c3\u03b9\u03ba\u03cc \u03c7\u03b7\u03bc\u03b9\u03ba\u03cc \u03c3\u03c4\u03bf\u03b9\u03c7\u03b5\u03af\u03bf \u03b5\u03af\u03bd\u03b1\u03b9 \u03c4\u03bf \u03c6\u03c5\u03bb\u03bb\u03b9\u03ba\u03cc \u03bf\u03be\u03cd (\u03bc\u03bf\u03c1\u03c6\u03ae \u03b2\u03b9\u03c4\u03b1\u03bc\u03af\u03bd\u03b7\u03c2). \u0397 Methotrexate \u03bb\u03bf\u03b9\u03c0\u03cc\u03bd, \u03bc\u03c0\u03bb\u03bf\u03ba\u03ac\u03c1\u03b5\u03b9 \u03c4\u03b7\u03bd \u03c3\u03cd\u03bd\u03b8\u03b5\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03a6\u03c5\u03bb\u03bb\u03b9\u03ba\u03bf\u03cd \u03bf\u03be\u03ad\u03c9\u03c2 \u03ba\u03b9 \u03ad\u03c4\u03c3\u03b9 \u03b5\u03bc\u03c0\u03bf\u03b4\u03af\u03b6\u03b5\u03b9 \u03c4\u03bf\u03bd \u03c0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03b1\u03c3\u03b9\u03b1\u03c3\u03bc\u03cc \u03c4\u03bf\u03c5 m RNA \u03c4\u03bf\u03c5 \u03b9\u03bf\u03cd \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03c3\u03cd\u03bd\u03b8\u03b5\u03c3\u03b7 \u03ba\u03b9 \u03ac\u03bb\u03bb\u03c9\u03bd \u03b5\u03bd\u03b6\u03cd\u03bc\u03c9\u03bd \u03ba\u03b1\u03b9 \u03c0\u03c1\u03c9\u03c4\u03b5\u03ca\u03bd\u03ce\u03bd, \u03bc\u03b5 \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03bd\u03b1 \u03c3\u03ba\u03bf\u03c4\u03ce\u03bd\u03b5\u03b9 \u03c4\u03bf\u03bd \u03b9\u03cc \u03c3\u03c4\u03b7\u03bd \u03ba\u03c5\u03c1\u03b9\u03bf\u03bb\u03b5\u03be\u03af\u03b1, \u03cc\u03c0\u03c9\u03c2 \u03c4` \u03b1\u03bd\u03c4\u03b9\u03b2\u03b9\u03bf\u03c4\u03b9\u03ba\u03ac \u03c4\u03b1 \u03ba\u03bf\u03b9\u03bd\u03ac \u03bc\u03b9\u03ba\u03c1\u03cc\u03b2\u03b9\u03b1. \u0393\u03b9\u03b1 \u03c4\u03bf\u03c5\u03c2 \u03bb\u03cc\u03b3\u03bf\u03c5\u03c2 \u03b1\u03c5\u03c4\u03bf\u03cd\u03c2, \u03ad\u03b4\u03b9\u03bd\u03b1\u03bd \u03c4\u03b7\u03bd Methotrexate \u03c0\u03b1\u03bb\u03b1\u03b9\u03cc\u03c4\u03b5\u03c1\u03b1 \u03c9\u03c2 \u03b1\u03bd\u03c4\u03b9-\u03ba\u03b1\u03c1\u03ba\u03b9\u03bd\u03b9\u03ba\u03cc \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03bf, \u03b4\u03b9\u03cc\u03c4\u03b9 \u03c3\u03c4\u03b1\u03bc\u03b1\u03c4\u03ac\u03b5\u03b9 \u03c4\u03bf\u03bd \u03c0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03b1\u03c3\u03b9\u03b1\u03b1\u03c3\u03bc\u03cc \u03c4\u03bf\u03c5 D\u039d\u0391 \u03ba\u03b1\u03b9 RNA \u03c4\u03c9\u03bd \u03ba\u03b1\u03c1\u03ba\u03b9\u03bd\u03b9\u03ba\u03ce\u03bd \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd. \u03a4\u03ce\u03c1\u03b1 \u03cc\u03bc\u03c9\u03c2 \u03b7 Methotrexate \u03c7\u03bf\u03c1\u03b7\u03b3\u03b5\u03af\u03c4\u03b1\u03b9 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03ba\u03b1\u03bb\u03bf\u03ae\u03b8\u03c9\u03bd \u03bd\u03cc\u03c3\u03c9\u03bd, \u03cc\u03c0\u03c9\u03c2 \u03c4\u03b7 \u03a8\u03c9\u03c1\u03af\u03b1\u03c3\u03b7\u03c2, \u03c4\u03b7\u03c2 \u03a8\u03c9\u03c1\u03b9\u03b1\u03c3\u03b9\u03ba\u03ae\u03c2 \u0391\u03c1\u03b8\u03c1\u03af\u03c4\u03b9\u03b4\u03b1\u03c2, \u03a1\u03b5\u03c5\u03bc\u03b1\u03c4\u03bf\u03b5\u03b9\u03b4\u03bf\u03cd\u03c2 \u0391\u03c1\u03b8\u03c1\u03af\u03c4\u03b9\u03b4\u03b1\u03c2, \u03c4\u03b7\u03c2 \u039d\u03cc\u03c3\u03bf\u03c5 \u03c4\u03bf\u03c5 Crohn, \u03c4\u03bf\u03c5 \u0395\u03c1\u03c5\u03b8\u03b7\u03bc\u03b1\u03c4\u03ce\u03b4\u03bf\u03c5\u03c2 \u039b\u03cd\u03ba\u03bf\u03c5, \u03b1\u03c4\u03bf\u03c0\u03b9\u03ba\u03ae\u03c2 \u03b4\u03b5\u03c1\u03bc\u03b1\u03c4\u03af\u03c4\u03b9\u03b4\u03b1\u03c2, \u03a3\u03b1\u03c1\u03ba\u03bf\u03b5\u03af\u03b4\u03c9\u03c3\u03b7\u03c2, \u039d\u03b5\u03bf\u03b1\u03bd\u03b9\u03ba\u03ae \u0394\u03b5\u03c1\u03bc\u03b1\u03c4\u03bf\u03bc\u03c5\u03bf\u03c3\u03af\u03c4\u03b7\u03c2 \u03ba\u03b9 \u03ac\u03bb\u03bb\u03c9\u03bd \u03b1\u03c5\u03c4\u03bf\u03ac\u03bd\u03bf\u03c3\u03c9\u03bd \u03bd\u03cc\u03c3\u03c9\u03bd (\u03bc\u03b5 \u03c4\u03bf\u03bd \u03af\u03b4\u03b9\u03bf \u03c4\u03c1\u03cc\u03c0\u03bf, \u03b7 Methotrexate) \u03b1\u03bd\u03b1\u03c3\u03c4\u03ad\u03bb\u03bb\u03b5\u03b9 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03c3\u03cd\u03bd\u03b8\u03b5\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03bd\u03bf\u03c5\u03ba\u03bb\u03bf\u03c3\u03b9\u03b4\u03af\u03bf\u03c5 \u0398\u03c5\u03bc\u03b9\u03b4\u03af\u03bd\u03b7, \u03c0\u03bf\u03c5 \u03c7\u03c1\u03b5\u03b9\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03c3\u03cd\u03bd\u03b8\u03b5\u03c3\u03b7 \u03c4\u03bf\u03c5 DNA). \u0395\u03af\u03bd\u03b1\u03b9 \u03c0\u03ac\u03bc\u03c6\u03b7\u03bd\u03bf, 7.5 \u03b5\u03c5\u03c1\u03ce \u03c4\u03bf \u03ba\u03bf\u03c5\u03c4\u03af.<\/p>\n<p><strong>\u0394\u039f\u03a3\u039f\u039b\u039f\u0393\u0399\u0391 Methotrexate:<\/strong> 2 \u03c7\u03ac\u03c0\u03b9\u03b1 \u03bc\u03b1\u03b6\u03af (2X2.5mg) \u03ba\u03ac\u03b8\u03b5 12 \u03ce\u03c1\u03b5\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03c1\u03b5\u03b9\u03c2 \u03c6\u03bf\u03c1\u03ad\u03c2(\u03c3\u03cd\u03bd\u03bf\u03bb\u03bf 6 \u03c7\u03ac\u03c0\u03b9\u03b1). \u0395\u03c0\u03b1\u03bd\u03b1\u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03b5\u03c4\u03b5 \u03bc\u03b5\u03c4\u03ac 1 \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03b1, \u03bc\u03ad\u03c7\u03c1\u03b9 \u03bd\u03b1 \u03b3\u03af\u03bd\u03b5\u03c4\u03b5 \u03ba\u03b1\u03bb\u03ac (\u03bd\u03bf\u03bc\u03af\u03b6\u03c9 \u03bc\u03b5 2 \u03ba\u03cd\u03ba\u03bb\u03bf\u03c5\u03c2 \u03b8\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03cc\u03bb\u03b1 \u03ba\u03b1\u03bb\u03ac (\u03ba\u03ac\u03b8\u03b5 \u03c7\u03ac\u03c0\u03b9 \u03c0\u03b5\u03c1\u03b9\u03ad\u03c7\u03b5\u03b9 2.5mg methotrexate) (\u03b2\u03bb.\u03ba\u03b1\u03b9 \u03c0\u03b1\u03c1\u03b1\u03ba\u03ac\u03c4\u03c9, \u03c6\u03c9\u03c4\u03bf\u03b3\u03c1\u03b1\u03c6\u03af\u03b1 \u03c4\u03bf\u03c5 \u03c6\u03c5\u03bb\u03bb\u03b1\u03b4\u03af\u03bf\u03c5 \u03c4\u03b7\u03c2 methotrexate \u03c4\u03b7\u03c2 \u03b5\u03c4\u03b1\u03b9\u03c1\u03b5\u03af\u03b1\u03c2 Pfizer).<\/p>\n<p>\u0391\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03b5\u03af\u03c2 \u03c4\u03b7\u03c2 \u0391\u03b3\u03b3\u03b5\u03b9\u03bf\u03c4\u03b5\u03bd\u03c3\u03af\u03bd\u03b7\u03c2-2: \u039b\u03b1\u03bc\u03b2\u03ac\u03bd\u03b5\u03c4\u03b1\u03b9 \u03c0\u03c1\u03bf\u03bb\u03b7\u03c0\u03c4\u03b9\u03ba\u03ac. \u03a4\u03bf \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03bf \u03b1\u03c5\u03c4\u03cc \u03b4\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03c9\u03c2 \u0391\u03bd\u03c4\u03b9-\u03a5\u03c0\u03b5\u03c1\u03c4\u03b1\u03c3\u03b9\u03ba\u03cc \u03ba\u03b1\u03b9 \u03bc\u03c0\u03bb\u03bf\u03ba\u03ac\u03c1\u03b5\u03b9 (\u03b1\u03bd\u03b1\u03c3\u03c4\u03ad\u03bb\u03bb\u03b5\u03b9) \u03c4\u03bf\u03c5\u03c2 \u03c7\u03b7\u03bc\u03b9\u03ba\u03bf\u03cd\u03c2 \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03b5\u03af\u03c2 (\u03c0\u03bf\u03c5 \u03b4\u03c1\u03bf\u03c5\u03bd \u03c3\u03b1\u03bd \u00ab\u03ba\u03bb\u03b5\u03b9\u03b4\u03b1\u03c1\u03cc\u03c4\u03c1\u03c5\u03c0\u03b1\u00bb) \u03c4\u03c9\u03bd \u03b1\u03bd\u03b8\u03c1\u03ce\u03c0\u03b9\u03bd\u03c9\u03bd \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03c0\u03bf\u03c5 \u03c5\u03c0\u03bf\u03b4\u03ad\u03c7\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c4\u03b7\u03bd \u0391\u03b3\u03b3\u03b3\u03b5\u03b9\u03c4\u03bf\u03bd\u03c3\u03af\u03bd\u03b7-2 (\u03c0\u03bf\u03c5 \u03b4\u03c1\u03b1 \u03c3\u03b1\u03bd \u00ab\u03ba\u03bb\u03b5\u03b9\u03b4\u03af\u00bb), \u03b7 \u03bf\u03c0\u03bf\u03af\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03b9\u03b1 \u03bf\u03c5\u03c3\u03af\u03b1 \u03c4\u03c9\u03bd \u03b5\u03c0\u03b9\u03bd\u03b5\u03c6\u03c1\u03b9\u03b4\u03af\u03c9\u03bd \u03c0\u03bf\u03c5 \u03b4\u03c1\u03b1 \u03c0\u03ac\u03bd\u03c9 \u03c3\u03c4\u03b1 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03c4\u03c9\u03bd \u03b1\u03b3\u03b3\u03b5\u03af\u03c9\u03bd \u03ba\u03b9 \u03b1\u03c5\u03be\u03ac\u03bd\u03b5\u03b9 \u03c4\u03b7\u03bd \u03c0\u03af\u03b5\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03b1\u03af\u03bc\u03b1\u03c4\u03bf\u03c2. \u039f \u03ba\u03bf\u03c1\u03bf\u03bd\u03bf\u03ca\u03cc\u03c2 \u03b4\u03c1\u03b1 \u03bc\u03b5 \u03c4\u03bf\u03bd \u03af\u03b4\u03b9\u03bf \u03c4\u03c1\u03cc\u03c0\u03bf \u03cc\u03c0\u03c9\u03c2 \u03b7 \u0391\u03b3\u03b3\u03b5\u03b9\u03bf\u03c4\u03b5\u03bd\u03c3\u03af\u03bd\u03b7-2, \u03b4\u03b7\u03bb\u03b1\u03b4\u03ae, \u03b7 \u03c0\u03c1\u03c9\u03c4\u03b5\u03ca\u03bd\u03b7 S (spike) \u03c4\u03bf\u03c5 \u03b9\u03bf\u03cd, \u03ba\u03bb\u03b5\u03b9\u03b4\u03ce\u03bd\u03b5\u03b9\u00bb \u03c3\u03b1\u03bd \u03ba\u03bb\u03b5\u03b9\u03b4\u03af \u03c3\u03b5 \u00ab\u03ba\u03bb\u03b5\u03b9\u03b4\u03b1\u03c1\u03cc\u03c4\u03c1\u03c5\u03c0\u03b1\u00bb \u03c0\u03ac\u03bd\u03c9 \u03c3\u03c4\u03bf\u03c5\u03c2 \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03b5\u03af\u03c2 \u03c4\u03b7\u03c2 \u0391\u03b3\u03b3\u03b5\u03b9\u03bf\u03c4\u03b5\u03bd\u03c3\u03af\u03bd\u03b7\u03c2-2 \u03c4\u03c9\u03bd \u03b1\u03bd\u03b8\u03c1\u03ce\u03c0\u03b9\u03bd\u03c9\u03bd \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd, \u03c4\u03b1 \u00ab\u03be\u03b5\u03ba\u03bb\u03b5\u03b9\u03b4\u03ce\u03bd\u03b5\u03b9\u00bb \u03ba\u03b9 \u03b5\u03c0\u03b9\u03c4\u03c1\u03ad\u03c0\u03b5\u03b9 \u03c4\u03b7\u03bd \u03b5\u03af\u03c3\u03bf\u03b4\u03bf \u03c3\u03c4\u03b1 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03c4\u03bf\u03c5 m RNA \u03c4\u03bf\u03c5 \u03b5\u03bc\u03b2\u03bf\u03bb\u03af\u03bf\u03c5 (\u03c0\u03bf\u03c5 \u03b5\u03af\u03bd\u03b1\u03b9 \u03ba\u03b1\u03b9 \u03c4\u03bf m RNA \u03c4\u03bf\u03c5 \u03b9\u03bf\u03cd, \u03bc\u03b5 \u03c4\u03b1 \u03b3\u03bd\u03c9\u03c3\u03c4\u03ac \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03c1\u03bf\u03c6\u03b9\u03ba\u03ac \u03b3\u03b9\u03b1 \u03c4\u03bf\u03bd \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae-\u03ba\u03b9 \u03cc\u03c7\u03b9 \u03b3\u03b9\u03b1 \u03c4\u03bf\u03bd \u03ba\u03bf\u03c1\u03bf\u03bd\u03bf\u03ca\u03cc!) \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03ad\u03c3\u03bc\u03b1\u03c4\u03b1. \u03a3\u03c5\u03bd\u03b5\u03c0\u03ce\u03c2, \u03b4\u03af\u03bd\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c4\u03bf\u03c5\u03c2 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03b5\u03af\u03c2 \u0391\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03b5\u03af\u03c2 \u03c4\u03b7\u03c2 \u0391\u03b3\u03b3\u03b5\u03b9\u03bf\u03c4\u03b5\u03bd\u03c3\u03af\u03bd\u03b7\u03c2-2, \u03b5\u03bc\u03c0\u03bf\u03b4\u03af\u03b6\u03bf\u03c5\u03bc\u03b5 \u03c4\u03b7\u03bd \u03b5\u03af\u03c3\u03bf\u03b4\u03bf \u03c4\u03bf\u03c5 \u03b9\u03bf\u03cd \u03c3\u03c4\u03b1 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1. \u0397 \u03b4\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03af\u03b1 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03c1\u03c5\u03b8\u03bc\u03b9\u03c3\u03c4\u03b5\u03af \u03b9\u03b4\u03b1\u03bd\u03b9\u03ba\u03ac \u03b1\u03c0\u03cc \u03b9\u03b1\u03c4\u03c1\u03cc \u03b3\u03b9\u03b1 \u03bd\u03b1 \u03bc\u03b7 \u03c0\u03ad\u03c3\u03b5\u03b9 \u03b7 \u03c0\u03af\u03b5\u03c3\u03ae \u03c3\u03b1\u03c2.<\/p>\n<p>\u03a4\u03b1 \u03c0\u03b1\u03c1\u03b1\u03c0\u03ac\u03bd\u03c9 \u03b4\u03cd\u03bf \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03b1, \u03b5\u03af\u03bd\u03b1\u03b9 \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03b1 \u03b3\u03bd\u03c9\u03c3\u03c4\u03ac, \u03b1\u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03b1 \u03ba\u03b1\u03b9 \u03c6\u03c4\u03b7\u03bd\u03ac. \u03a4\u03b1 \u03ad\u03c7\u03c9 \u03c0\u03c1\u03bf\u03c4\u03b5\u03af\u03bd\u03b5\u03b9 \u03c3\u03c4\u03bf\u03bd \u0395\u039f\u0394\u03a5 \u03ba\u03b1\u03b9 \u03c4\u03b9\u03c2 \u03ac\u03bb\u03bb\u03b5\u03c2 \u03b1\u03c1\u03c7\u03ad\u03c2 \u03b1\u03c0\u03cc \u03c0\u03ad\u03c1\u03b9\u03c3\u03c5\u2026.\u03b1\u03bb\u03bb\u03ac\u2026\u03c9\u03c2 \u03c3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03b1\u03b3\u03bd\u03bf\u03ae\u03b8\u03b7\u03ba\u03b1, \u03bc\u03c0\u03c1\u03bf\u03c3\u03c4\u03ac \u03c3\u03c4\u03bf \u03bc\u03b5\u03b3\u03b1\u03bb\u03b5\u03af\u03bf \u03c4\u03bf\u03c5 \u03a4\u03c3\u03b9\u03cc\u03b4\u03c1\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03c2 \u0391\u03c3\u03c0\u03b1\u03c3\u03af\u03b1\u03c2 \u03c4\u03bf\u03c5 \u039a\u03b1\u03c1\u03b1\u03b3\u03ba\u03b9\u03cc\u03b6\u03b7.<\/p>\n<p>\u039c\u03b5 \u03b1\u03b3\u03ac\u03c0\u03b7, \u039a\u03b1\u03bb\u03cc \u03ba\u03bf\u03c5\u03c1\u03ac\u03b3\u03b9\u03bf, \u03b7 \u0391\u03bb\u03ae\u03b8\u03b5\u03b9\u03b1 \u03b4\u03b5\u03bd \u03ba\u03c1\u03cd\u03b2\u03b5\u03c4\u03b1\u03b9. \u0391\u03c1\u03ba\u03b5\u03af \u03bd\u03b1 \u03bc\u03b7\u03bd \u03c0\u03bb\u03b7\u03c1\u03ce\u03bd\u03b5\u03b9 \u03b7 \u03b1\u03bd\u03b8\u03c1\u03c9\u03c0\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03c1\u03b1\u03b3\u03b9\u03ba\u03cc \u03c4\u03af\u03bc\u03b7\u03bc\u03b1 \u03bc\u03ad\u03c7\u03c1\u03b9 \u03c4\u03bf\u03bd \u03b8\u03c1\u03af\u03b1\u03bc\u03b2\u03cc \u03c4\u03b7\u03c2.<\/p>\n<p>\u039a\u0399\u00a0<strong><a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.26512#\" target=\"_blank\" rel=\"noopener noreferrer\">\u0395\u0394\u03a9<\/a><\/strong>\u00a0\u03bc\u03b9\u03b1 \u03b1\u03c0\u03cc \u03c4\u03b9\u03c2 \u03c0\u03bf\u03bb\u03bb\u03ad\u03c2 \u03b4\u03b9\u03b5\u03b8\u03bd\u03b5\u03af\u03c2 \u03ad\u03c1\u03b5\u03c5\u03bd\u03b5\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03bc\u03b5\u03b8\u03bf\u03c4\u03c1\u03b5\u03be\u03ac\u03c4\u03b7, \u03c0\u03bf\u03c5 \u03b5\u03c0\u03b9\u03b2\u03b5\u03b2\u03b1\u03b9\u03ce\u03bd\u03bf\u03c5\u03bd \u03cc\u03bb\u03b1 \u03cc\u03c3\u03b1 \u03c0\u03b1\u03c1\u03b1\u03c0\u03ac\u03bd\u03c9 \u03bb\u03ad\u03c9:<\/p>\n<p>In early 2020 the new respiratory syndrome COVID\u201019 (caused by the zoonotic SARS\u2010CoV\u20102 virus) spread like a pandemic, starting from Wuhan, China, causing severe economic depression. Despite some advances in drug treatments of medical complications in the later stages of the disease, the pandemic\u2019s death toll is tragic, as no vaccine or specific antiviral treatment is currently available. By using a systems approach, we identify the host\u2010encoded pathway, which provides ribonucleotides to viral RNA synthesis, as a possible target. We show that methotrexate, an FDA\u2010approved inhibitor of purine biosynthesis, potently inhibits viral RNA replication, viral protein synthesis, and virus release. The effective antiviral methotrexate concentrations are similar to those used for established human therapies using the same drug. Methotrexate should be most effective in patients at the earliest appearance of symptoms to effectively prevent viral replication, diffusion of the infection, and possibly fatal complications\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026..<\/p>\n<p><strong>\u039a\u03b9\u00a0<a href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04610567\" target=\"_blank\" rel=\"noopener noreferrer\">\u03b5\u03b4\u03ce<\/a> \u03b7 \u039c\u03b5\u03b8\u03bf\u03c4\u03c1\u03b5\u03be\u03ac\u03c4\u03b7 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c0\u03bb\u03ad\u03bf\u03bd \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03c4\u03bf\u03c5 \u03ba\u03bf\u03c1\u03bf\u03bd\u03bf\u03ca\u03bf\u03cd \u03c3\u03c4\u03b7\u03bd \u0391\u03bc\u03b5\u03c1\u03b9\u03ba\u03ae:<\/strong><\/p>\n<div>\n<p><strong><a href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04610567\" target=\"_blank\" rel=\"noopener noreferrer\">Treatment of Patients With Mild Coronavirus-19 (COVID-19) Disease With Methotrexate Associated to LDL Like Nanoparticles (Nano-COVID19) (Nano-COVID19)<\/a><\/strong><\/p>\n<p>\u03a0\u03b5\u03c1\u03b1\u03b9\u03c4\u03ad\u03c1\u03c9 \u03c0\u03b1\u03c1\u03ac\u03b4\u03b5\u03b9\u03b3\u03bc\u03b1 \u03c7\u03c1\u03ae\u03c3\u03b7\u03c2 \u03c4\u03b7\u03c2 \u039c\u03b5\u03b8\u03bf\u03c4\u03c1\u03b5\u03be\u03ac\u03c4\u03b7\u03c2 \u03ba\u03b1\u03b9 <strong><a href=\"https:\/\/www.mdedge.com\/dermatology\/article\/228614\/coronavirus-updates\/covid-19-outcomes-no-worse-patients-tnf-inhibitors-or\" target=\"_blank\" rel=\"noopener noreferrer\">\u03b5\u03b4\u03ce<\/a><\/strong>.<\/p>\n<p><strong>Methotrexate Receives FDA Approval for Treatment of Rheumatoid Arthritis<\/strong><br \/>\n<strong>December 3, 2019<\/strong><br \/>\n<strong><a href=\"https:\/\/www.pharmacytimes.com\/authors\/jill-murphy-assistant-editor\" target=\"_blank\" rel=\"noopener noreferrer\">Jill Murphy, Assistant Editor<\/a><\/strong><\/p>\n<p>Officials from the FDA have approved methotrexate (RediTrex, Cumberland Pharmaceuticals) as an injection for the treatment of adult and pediatric patients with rheumatoid arthritis.<\/p>\n<p><strong>\u0395\u0394\u03a9<\/strong>\u00a0<strong><a href=\"https:\/\/www.pharmacytimes.com\/view\/methotrexate-receives-fda-approval-for-treatment-of-rheumatoid-arthritis\" target=\"_blank\" rel=\"noopener noreferrer\">\u039f FDA (\u03bf \u03bf\u03c1\u03b3\u03b1\u03bd\u03b9\u03c3\u03bc\u03cc\u03c2 \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03c9\u03bd \u03c4\u03c9\u03bd \u0397\u03a0\u0391 \u03b5\u03bd\u03ad\u03ba\u03c1\u03b9\u03bd\u03b5 \u03c4\u03b7\u03bd \u039c\u03b5\u03b8\u03bf\u03c4\u03c1\u03b5\u03be\u03ac\u03c4\u03b7 \u03b3\u03b9\u03b1 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03c4\u03b7\u03c2 \u03c1\u03b5\u03c5\u03bc\u03b1\u03c4\u03bf\u03b5\u03b9\u03b4\u03bf\u03cd\u03c2 \u03b1\u03c1\u03b8\u03c1\u03af\u03c4\u03b9\u03b4\u03b1\u03c2<\/a><\/strong><\/p>\n<p>Officials from the FDA have approved methotrexate (RediTrex, Cumberland Pharmaceuticals) as an injection for the treatment of adult and pediatric patients with rheumatoid arthritis. The injection is also indicated for adults with psoriasis, according to the company.<\/p>\n<p>Methotrexate is approved as both an oral and injectable treatment in the United States. Injectable methotrexate has been shown to result in increased efficacy, greater continuation rates, and less discomfort for patients, while oral formulations are more widely available.<\/p>\n<div class=\"code-block code-block-8\"><\/div>\n<p>Cumberland, a specialty pharmaceutical company, will launch 2 injectable methotrexate product lines within the US, with both products intended for the treatment of active rheumatoid arthritis, juvenile idiopathic arthritis, and severe psoriasis.<\/p>\n<p><strong>\u03a0\u0391\u03a1\u0391\u039a\u0391\u039b\u03a9 \u03a0\u039f\u039b\u03a5\u2026\u0394\u0399\u0391\u0394\u03a9\u03a3\u03a4\u0395 \u03c4\u03b7\u03bd \u03c0\u03b1\u03c1\u03bf\u03cd\u03c3\u03b1 \u0391\u039d\u0391\u03a1\u03a4\u0397\u03a3\u0397 \u039c\u039f\u03a5\u2026\u03bd\u03b1 \u03c3\u03c9\u03b8\u03b5\u03af \u03bf \u03ba\u03cc\u03c3\u03bc\u03bf\u03c2<\/strong><\/p>\n<p><strong>\u0394\u03b7\u03bc. \u0391\u03bd\u03c4\u03c9\u03bd\u03af\u03bf\u03c5, \u03b9\u03b1\u03c4\u03c1\u03cc\u03c2<\/strong><\/p>\n<p><strong>\u03a4\u03bf \u03c6\u03c5\u03bb\u03bb\u03ac\u03b4\u03b9\u03bf \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b4\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03af\u03b1 \u03c4\u03b7\u03c2 Methotrexate \u03c4\u03b7\u03c2 \u03b5\u03c4\u03b1\u03b9\u03c1\u03b5\u03af\u03b1\u03c2 Pfizer<\/strong><\/p>\n<p><a href=\"https:\/\/www.triklopodia.gr\/wp-content\/uploads\/2021\/05\/METHOTREXATE-4.jpg\" rel=\"prettyPhoto\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-589959\" title=\"METHOTREXATE-4\" src=\"https:\/\/www.triklopodia.gr\/wp-content\/uploads\/2021\/05\/METHOTREXATE-4.jpg\" sizes=\"auto, (max-width: 452px) 100vw, 452px\" srcset=\"https:\/\/www.triklopodia.gr\/wp-content\/uploads\/2021\/05\/METHOTREXATE-4.jpg 452w, https:\/\/www.triklopodia.gr\/wp-content\/uploads\/2021\/05\/METHOTREXATE-4-212x300.jpg 212w\" alt=\"\" width=\"452\" height=\"640\" \/>\u03a0\u0397\u0393\u0397:https:\/\/www.triklopodia.gr\/%ce%b4%cf%81-%ce%b4-%ce%b1%ce%bd%cf%84%cf%89%ce%bd%ce%af%ce%bf%cf%85-%ce%b7-%cf%80%cf%81%ce%bf%cf%84%ce%b5%ce%b9%ce%bd%cf%8c%ce%bc%ce%b5%ce%bd%ce%b7-%ce%b8%ce%b5%cf%89%cf%81%ce%b7%cf%84%ce%b9%ce%ba\/<\/a><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u039f\u00a0\u0394\u03c1. \u0394\u03b7\u03bc\u03ae\u03c4\u03c1\u03b9\u03bf\u03c2 \u0391\u03bd\u03c4\u03c9\u03bd\u03af\u03bf\u03c5 PhD, FRCS\u00a0\u03c0\u03c1\u03bf\u03c4\u03b5\u03af\u03bd\u03b5\u03b9 \u03c4\u03b7\u03bd \u03b1\u03bd\u03c4\u03b9\u03bc\u03b5\u03c4\u03ce\u03c0\u03b9\u03c3\u03b7 \u03c4\u03bf\u03c5 Covid \u03bc\u03b5 \u03c6\u03b8\u03b7\u03bd\u03ac \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03b1 \u03c4\u03b1 \u03bf\u03c0\u03bf\u03af\u03b1 \u03c7\u03bf\u03c1\u03b7\u03b3\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03b3\u03b9\u03b1 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03c0\u03b1\u03b8\u03ae\u03c3\u03b5\u03b9\u03c2 \u03ba\u03b1\u03b9 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b4\u03b9\u03b1\u03b8\u03ad\u03c3\u03b9\u03bc\u03b1 \u03c3\u03c4\u03bf \u03c6\u03b1\u03c1\u03bc\u03b1\u03ba\u03b5\u03af\u03b1. \u03a3\u03c4\u03bf \u03c0\u03b1\u03c1\u03cc\u03bd \u03ac\u03c1\u03b8\u03c1\u03bf \u03b5\u03be\u03b7\u03b3\u03b5\u03af \u03c4\u03b7\u03bd \u03b4\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03af\u03b1 \u03c0\u03bf\u03c5 \u03b8\u03b1 \u03c0\u03c1\u03cc\u03c4\u03b5\u03b9\u03bd\u03b5 \u03c3\u03c4\u03bf\u03c5\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03c4\u03bf\u03c5, \u03c0\u03c1\u03bf\u03c4\u03c1\u03ad\u03c0\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c4\u03b7\u03bd \u03ba\u03bf\u03b9\u03bd\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03ae \u03c4\u03bf\u03c5\u03c2 \u03ce\u03c3\u03c4\u03b5 \u03bd\u03b1 \u03b3\u03bd\u03c9\u03c1\u03af\u03b6\u03b5\u03b9 \u03bf \u03ba\u03cc\u03c3\u03bc\u03bf\u03c2. \u03a0\u03c1\u03bf\u03c4\u03b5\u03b9\u03bd\u03cc\u03bc\u03b5\u03bd\u03b7 \u03b8\u03b5\u03c9\u03c1\u03b7\u03c4\u03b9\u03ba\u03ac \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03bc\u03b5 \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03b1 \u03b3\u03b9\u03b1 \u03c4\u03bf\u03bd \u03ba\u03bf\u03c1\u03bf\u03bd\u03bf\u03b9\u03cc: Methotrexate (\u03b3\u03b9\u03b1 &hellip; <\/p>\n<p><a class=\"more-link btn\" href=\"https:\/\/evaggelatos.com\/?p=20623\">\u03a3\u03c5\u03bd\u03ad\u03c7\u03b5\u03b9\u03b1 \u03b1\u03bd\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7\u03c2<\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[85],"tags":[229,244],"class_list":["post-20623","post","type-post","status-publish","format-standard","hentry","category-85","tag-229","tag-244","item-wrap"],"_links":{"self":[{"href":"https:\/\/evaggelatos.com\/index.php?rest_route=\/wp\/v2\/posts\/20623","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/evaggelatos.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/evaggelatos.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/evaggelatos.com\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/evaggelatos.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=20623"}],"version-history":[{"count":7,"href":"https:\/\/evaggelatos.com\/index.php?rest_route=\/wp\/v2\/posts\/20623\/revisions"}],"predecessor-version":[{"id":20631,"href":"https:\/\/evaggelatos.com\/index.php?rest_route=\/wp\/v2\/posts\/20623\/revisions\/20631"}],"wp:attachment":[{"href":"https:\/\/evaggelatos.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=20623"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/evaggelatos.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=20623"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/evaggelatos.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=20623"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}