{"id":24132,"date":"2021-12-21T23:16:12","date_gmt":"2021-12-21T23:16:12","guid":{"rendered":"https:\/\/evaggelatos.com\/?p=24132"},"modified":"2021-12-21T23:17:21","modified_gmt":"2021-12-21T23:17:21","slug":"%ce%ba%ce%b1%ce%bb%ce%bb%ce%b9%ce%b5%cf%81%ce%b3%ce%b7%ce%bc%ce%ad%ce%bd%ce%b7-spike-proteine-%cf%83%ce%b5-%ce%bd%cf%85%cf%87%cf%84%ce%bf%cf%80%ce%b5%cf%84%ce%b1%ce%bb%ce%bf%cf%8d%ce%b4%ce%b1-%ce%bc","status":"publish","type":"post","link":"https:\/\/evaggelatos.com\/?p=24132","title":{"rendered":"\u039a\u03b1\u03bb\u03bb\u03b9\u03b5\u03c1\u03b3\u03b7\u03bc\u03ad\u03bd\u03b7 spike proteine \u03c3\u03b5 \u03bd\u03c5\u03c7\u03c4\u03bf\u03c0\u03b5\u03c4\u03b1\u03bb\u03bf\u03cd\u03b4\u03b1 \u03bc\u03b1\u03b6\u03af \u03bc\u03b5 \u03c3\u03b1\u03c0\u03bf\u03bd\u03af\u03bd\u03b7 \u03c6\u03b1\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bd\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf \u03b5\u03bc\u03b2\u03cc\u03bb\u03b9\u03bf \u03b3\u03b9\u03b1 \u03cc\u03c3\u03bf\u03c5\u03c2 \u03c6\u03bf\u03b2\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03c4\u03b9\u03c2 \u03c0\u03b1\u03c1\u03b5\u03bd\u03ad\u03c1\u03b3\u03b5\u03b9\u03b5\u03c2 \u03c4\u03c9\u03bd mRna \u03ba\u03b1\u03b9 DNA \u03b5\u03bc\u03b2\u03bf\u03bb\u03af\u03c9\u03bd"},"content":{"rendered":"<div>\n<div id=\"block-pagetitle\">\n<div class=\"page-title\" aria-label=\"Moths and tree bark: How the Novavax vaccine works\">\n<div class=\"container\">\n<div class=\"row\">\n<div class=\"col-md-12\">\n<h1>Moths and tree bark: How the Novavax vaccine works<\/h1>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"layout-content\">\n<div class=\"container\">\n<div class=\"row\">\n<div class=\"col-sm-8 col-md-9\">\n<div>\n<div id=\"block-breadcrumbs\">\n<div class=\"row\">\n<div class=\"col-md-12\">\n<nav class=\"breadcrumb\" role=\"navigation\" aria-label=\"Breadcrumb\"><a href=\"https:\/\/www.nebraskamed.com\/\">Home<\/a> <a href=\"https:\/\/www.nebraskamed.com\/COVID\">Coronavirus (COVID-19)<\/a> <a href=\"https:\/\/www.nebraskamed.com\/COVID\/moths-and-tree-bark-how-the-novavax-vaccine-works\">Moths and tree bark: How the Novavax vaccine works<\/a><\/nav>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"container\">\n<div class=\"row\">\n<div class=\"col-sm-8 col-md-9\">\n<div>\n<div id=\"block-mainpagecontent\">\n<article role=\"article\">\n<div class=\"author-info row\">\n<div class=\"author-info__right\">\n<p>Published <time datetime=\"2021-06-25T15:23:05Z\">June 25, 2021<\/time><\/p>\n<\/div>\n<\/div>\n<div>\n<div>\n<p>&nbsp;<\/p>\n<figure><img loading=\"lazy\" decoding=\"async\" class=\"\" src=\"https:\/\/www.nebraskamed.com\/sites\/default\/files\/images\/covid19\/novavaxhowitworks_blog.jpg\" alt=\"Cheryl Logan, EdD, superintendent of Omaha Public Schools, participated in the phase 3 clinical trial led by Diana Florescu, MD, at the University of Nebraska Medical Center.\" width=\"758\" height=\"429\" data-entity-type=\"\" data-entity-uuid=\"\" \/><figcaption>Cheryl Logan, EdD, superintendent of Omaha Public Schools, participated in the phase 3 clinical trial led by Diana Florescu, MD, at the University of Nebraska Medical Center.<\/figcaption><\/figure>\n<p>&nbsp;<\/p>\n<p>Novavax has created a fourth COVID-19 vaccine using moth cells and tree bark. Instead of an mRNA vaccine (Pfizer, Moderna) or a viral vector vaccine (Johnson &amp; Johnson), Novavax is a subunit protein vaccine.<\/p>\n<p>Infectious diseases expert <a href=\"https:\/\/www.nebraskamed.com\/doctors\/diana-f-florescu\">Diana Florescu, MD<\/a>, led the phase 3 clinical trial of the Novavax vaccine at the University of Nebraska Medical Center (UNMC). &#8220;Diversity in vaccine production helps increase the number of patients vaccinated,&#8221; says Dr. Florescu. &#8220;Some might not accept mRNA vaccines, while others may be allergic to certain ingredients.&#8221;<\/p>\n<p>For example, some are allergic to polyethylene glycol (PEG), an <a href=\"https:\/\/www.nebraskamed.com\/COVID\/you-asked-we-answered-are-covid-19-vaccine-ingredients-public\">ingredient<\/a> in the mRNA (Pfizer and Moderna) vaccines. <a href=\"https:\/\/www.sciencemag.org\/news\/2020\/12\/novavax-launches-pivotal-us-trial-dark-horse-covid-19-vaccine-after-manufacturing\" target=\"_blank\" rel=\"noopener\"><strong>There&#8217;s no polyethylene glycol (PEG) in Novavax<\/strong><\/a><strong>.\u00a0<\/strong><\/p>\n<h3>How does the Novavax vaccine work?<\/h3>\n<p><strong>The Novavax COVID-19 vaccine contains a protein (made using moth cells) plus an adjuvant (made from tree bark). An adjuvant is an ingredient added to boost a person&#8217;s immune response, creating higher levels of antibodies.<\/strong><\/p>\n<p>The Novavax vaccine uses a telltale piece of the coronavirus: the notorious spike protein. All alone, the spike protein is harmless and can&#8217;t cause COVID-19. When your immune system encounters the lonely spike protein, it produces antibodies against it. This gives you protection against future COVID-19 infection.<\/p>\n<p>&#8220;Unlike mRNA vaccines, the spike protein is already premade in the Novavax vaccine. It&#8217;s a shortcut,&#8221; explains Dr. Florescu. &#8220;All the synthesis happens outside the body and we just give the end product: the spike protein.&#8221;<\/p>\n<p>Like other COVID-19 vaccines, Novavax does not cause COVID-19 infection. It can&#8217;t get you sick. This vaccine doesn&#8217;t contain either live or inactivated virus.<\/p>\n<h3>How did they get the spike protein?<\/h3>\n<p>The Novavax method uses moth cells to make spike proteins:<\/p>\n<ol>\n<li>Researchers select the desired genes that create certain SARS-CoV-2 antigens (spike protein).<\/li>\n<li>Researchers put the genes into a baculovirus, an insect virus.<\/li>\n<li>The baculovirus infects moth cells and replicates inside them.<\/li>\n<li>These moth cells create lots of spike proteins.<\/li>\n<li>Researchers extract and purify the spike proteins.<\/li>\n<\/ol>\n<p>&#8220;The Novavax vaccine has no genetic material, only proteins,&#8221; says Dr. Florescu. &#8220;The vaccine technology is more traditional, and it&#8217;s very similar to a protein-based influenza vaccine.&#8221;<\/p>\n<p>Influenza vaccines have also used this <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7150248\/\" target=\"_blank\" rel=\"noopener\">moth cell factory method<\/a>.<\/p>\n<h3>What does the adjuvant (soapbark tree extract) do?<\/h3>\n<p>Adjuvants increase the immune response to a vaccine. In this vaccine, soapbark tree extract adjuvant makes achieving immunity possible with a smaller dose of the spike protein.<\/p>\n<p>Matrix-M is the adjuvant used by Novavax. It is based on a saponin extracted from the soapbark tree<strong> (Quillaja saponaria)<\/strong>. <strong>The soapbark extract encourages immune cells to activate, generating a more potent immune response.\u00a0<\/strong><\/p>\n<p>Saponins are found naturally in various plant species like beans and green peas. They&#8217;re used in agriculture, animal feeds, veterinary vaccines and human food. Saponins can boost immune responses to proteins.<strong> Using the Matrix-M adjuvant, a smaller dose of spike protein achieves the desired immune response.\u00a0<\/strong><\/p>\n<p>See how well the Novavax vaccine performed in phase 3 clinical trials <a href=\"https:\/\/www.nebraskamed.com\/COVID\/novavax-vaccine-results-how-effective-is-it-against-variants\">here<\/a>.<\/p>\n<p>SOURCE:https:\/\/www.nebraskamed.com\/COVID\/moths-and-tree-bark-how-the-novavax-vaccine-works<\/p>\n<\/div>\n<\/div>\n<\/article>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Moths and tree bark: How the Novavax vaccine works Home Coronavirus (COVID-19) Moths and tree bark: How the Novavax vaccine works Published June 25, 2021 &nbsp; Cheryl Logan, EdD, superintendent of Omaha Public Schools, participated in the phase 3 clinical trial led by Diana Florescu, MD, at the University of Nebraska Medical Center. &nbsp; Novavax &hellip; <\/p>\n<p><a class=\"more-link btn\" href=\"https:\/\/evaggelatos.com\/?p=24132\">\u03a3\u03c5\u03bd\u03ad\u03c7\u03b5\u03b9\u03b1 \u03b1\u03bd\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7\u03c2<\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[85],"tags":[90],"class_list":["post-24132","post","type-post","status-publish","format-standard","hentry","category-85","tag-90","item-wrap"],"_links":{"self":[{"href":"https:\/\/evaggelatos.com\/index.php?rest_route=\/wp\/v2\/posts\/24132","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/evaggelatos.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/evaggelatos.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/evaggelatos.com\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/evaggelatos.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=24132"}],"version-history":[{"count":2,"href":"https:\/\/evaggelatos.com\/index.php?rest_route=\/wp\/v2\/posts\/24132\/revisions"}],"predecessor-version":[{"id":24134,"href":"https:\/\/evaggelatos.com\/index.php?rest_route=\/wp\/v2\/posts\/24132\/revisions\/24134"}],"wp:attachment":[{"href":"https:\/\/evaggelatos.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=24132"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/evaggelatos.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=24132"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/evaggelatos.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=24132"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}